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Today I learned there are language tags ‘en-001’ and ‘en-150’ for World and European English. The former is a better default than ‘en’, which browsers still associate with American-specific conventions like month-day-year dates.
One of my bugbears is user databases that assume or impose first-name, surname fields, based on assumptions about how people's names are structured. This W3C note on personal names around the world outlines some of the ways names are understood around the world, and has suggestions for designing UIs accordingly.